Gap junction modulation by extracellular signaling molecules: the thymus model
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چکیده
منابع مشابه
Gap junction modulation by extracellular signaling molecules: the thymus model.
Gap junctions are intercellular channels which connect adjacent cells and allow direct exchange of molecules of low molecular weight between them. Such a communication has been described as fundamental in many systems due to its importance in coordination, proliferation and differentiation. Recently, it has been shown that gap junctional intercellular communication (GJIC) can be modulated by se...
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In many tissues cells communicate directly through arrays of intercellular channels which are organized to form gap junctions. These channels are permeant to inorganic ions as well as to small hydrophilic molecules up to Mr 2000. The electrical and chemical coupling provided by such junctions is under the control of intracellular and, in many cases, extracellular substances. The latter (hormone...
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BACKGROUND Recent studies suggested that cardiac conduction in murine hearts with narrow perinexi and 50% reduced connexin43 (Cx43) expression is more sensitive to relatively physiological changes of extracellular potassium ([K(+)]o) and sodium ([Na(+)]o). PURPOSE Determine whether similar [K(+)]o and [Na(+)]o changes alter conduction velocity (CV) sensitivity to pharmacologic gap junction (G...
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ژورنال
عنوان ژورنال: Brazilian Journal of Medical and Biological Research
سال: 2000
ISSN: 0100-879X
DOI: 10.1590/s0100-879x2000000400012